STEM CELLULAR™  · Anti-Wrinkle Retinol Overnight Serum

Wake up to smoother, more even skin.

2.5% Bio-Retinol + Retinol Complex™ minimizes the look of fine lines, wrinkles, dark spots and discoloration, and promotes smooth, radiant skin. The retinol is encapsulated in evening primrose to keep it stable.
$72.00 30 mL / 1 fl oz ★★★★★ 4.8 690+ reviews
2.5% Bio-Retinol + Retinol Encapsulated for stability Face, neck and décolleté Night use
Stem Cellular Anti-Wrinkle Retinol Overnight Serum bottle by Juice Beauty
2.5%
Bio-Retinol + Retinol Complex™
4.8
Stars · 690+ reviews
1–2
nights a week to start, then build

BEFORE & AFTER

See the difference on real skin.

Drag to compare, and switch between the two panel participants. Instrument-measured photography from a third party lab consumer panel test.
Before resultAfter result
BEFOREAFTER

Third party lab consumer panel test. Individual results may vary

Smooths

Minimizes the appearance of fine lines and wrinkles, and the look of skin roughness.

Evens

Minimizes the look of dark spots and discoloration, and helps visibly even skin tone.

Plumps

Hyaluronic acid hydrates and visibly plumps overnight, for a softer, smoother-looking appearance.

Approved product claim: 2.5% Bio-Retinol + Retinol minimizes fine lines, wrinkles, dark spots and discoloration and promotes smooth, radiant skin.

Why it's different

Retinol that works without stripping your skin.

  • Encapsulated, not raw

    The retinol is encapsulated in evening primrose. Encapsulation protects retinol's stability, which is the difference between a serum that still works at the end of the bottle and one that does not.

  • Two forms of retinol, not one

    2.5% Bio-Retinol + Retinol Complex™, working together on the look of fine lines and wrinkles.

  • Cushioned by the base it sits in

    Jojoba, shea and murumuru butters, hyaluronic acid, vitamin E and panthenol are in the formula alongside the retinol, not sold separately as the thing that repairs the damage.

  • Built on juice, not filler water

    SuperJuice Complex™ replaces conventional filler water with organic grape, apple, aloe and lemon juices, so the base is nutrient-dense from the first drop. Over 2,000 ingredients are excluded by design.

Stem Cellular Anti-Wrinkle Retinol Overnight Serum ingredients tile featuring jojoba, coconut, and shea butters with hyaluronic acid
WHAT'S INSIDE

2.5% retinol, cushioned by plant oils and hyaluronic acid.

A retinol serum is only as good as what surrounds the retinol. Here is the short list.
Rejuvenate, Firm, Replenish

2.5% Bio-Retinol +Retinol Complex™

The active pairing, targeting the look of fine lines and wrinkles. The retinol is encapsulated in evening primrose, which protects its stability.
INCI: oenothera biennis (evening primrose) leaf cell extract / [retinol/soybean]

Hyaluronic acid and panthenol

Hydrate and visibly plump overnight. Well-hydrated skin tolerates retinol better, which is why they are in the same bottle.
INCI: sodium hyaluronate, panthenol (Vitamin B5)

Jojoba, shea and murumuru

Plant butters and oils that keep the formula cushioned rather than stripping.
INCI: simmondsia chinensis (jojoba) seed oil, butyrospermum parkii (shea) butter, astrocaryum murumuru seed butter

Sagrantino SuperGrapeand plant stem cells

The STEM CELLULAR™ signature. Grape, apple and lemon fruit cell extracts with green tea, in an antioxidant-rich base.
INCI: vitis vinifera (grape) fruit cell extract, malus domestica (apple) fruit cell culture extract, camellia sinensis (green tea) extract

Vitamins C, E, B5 andCoQ10

Antioxidant support layered into the same formula.
INCI: magnesium ascorbyl phosphate (Vitamin C), tocopherol (Vitamin E), ubiquinone(CoQ 10), thioctic acid (alpha lipoic)

START HERE

Start once a week, then build up.

Most people who give up on retinol started too fast. Tell us where your skin is and we will give you a schedule.

RETINOL SCHEDULE

One question, one plan

HAVE YOU USED RETINOL BEFORE?
YOUR SCHEDULE

Start at once a week

Weeks 1–2Once a week, at night. See how your skin responds before you add a second night.
Weeks 3–4Twice a week, if week two passed without dryness or irritation.
Weeks 5–8Every other night, building slowly.
Week 9 onNightly, only if your skin is comfortable. Plenty of people stay at every other night.

Apply at night to face, neck and décolleté, before your moisturizer. Broad spectrum SPF every morning.

Start low and cushion it

Weeks 1–3Once a week, at night, on a night you have not exfoliated.
Weeks 4–6Twice a week. Moisturize straight over the top if you feel tightness.
Weeks 7–10Every third night, then every other night as it settles.
OngoingEvery other night is a perfectly good place to stay. Do not chase nightly.

Apply at night to face, neck and décolleté, before your moisturizer. Broad spectrum SPF every morning.

Move up at your own pace

Week 1Every other night, to check how your skin takes this formula.
Weeks 2–3Every other night, or nightly if there is no dryness.
Week 4 onNightly as tolerated, face, neck and décolleté.
Any timeDrop back a step if you get flaking, tightness or stinging.

Apply at night to face, neck and décolleté, before your moisturizer. Broad spectrum SPF every morning.

Three Rules

Always at night

Retinol is most effective applied at night, before you moisturize.

Three Rules

Always with SPF

Wear a broad spectrum sunscreen every morning while you are using retinol. This is not optional.

Three Rules

Hydrate first

Make sure your skin is well hydrated, especially when you are starting out.

If your skin is reacting, drop back a step rather than pushing through. Some people stay at once or twice a week and are happy there.

THE PM ROUTINE

The rejuvenating 4-step night routine.

01

Cleanse

STEM CELLULAR 2-in-1 Cleanser. Lather in wet palms, massage into damp skin for at least a minute, rinse and pat dry.

02

Treat

Anti-Wrinkle Retinol Overnight Serum. Apply at night to face, neck and décolleté, building up as tolerated.

03

Eyes

SleepWrinkle Retinol Overnight Eye Cream. Massage around the entire eye from the inner corner, then pat in the excess.

04

Seal

Anti-Wrinkle Ceramide Overnight Cream. Seals in the moisture. No retinol in this one, it is the moisture step.

Retinol Duo

STEM CELLULAR™

SleepWrinkle Retinol Overnight Eye Cream 

2.5% Bio-Retinol + Retinol for the eye area. $45

97% showed improvement in appearance of eye area fine lines and wrinkles*

SHOP

STEM CELLULAR™

Anti-Wrinkle Ceramide Overnight Cream

The moisture-seal step. No retinol.

91% improved moisture replenishment overnight†

SHOP

EVERY MORNING

PREBIOTIX SPF 45 Glow Daily Multi-Tasking Moisturizer 

Broad spectrum mineral SPF 45. Retinol at night only works if you protect in the morning. $39.50

SHOP

*Digital image instrument analysis on the SleepWrinkle Retinol Overnight Eye Cream. Independent 4 week lab analysis. Individual results may vary. †3rd party lab, after 5 weeks, on the Anti-Wrinkle Ceramide Overnight Cream. Individual results may vary. Both claims belong to those products and must never be attached to this serum.

WHY PEOPLE LOVE IT

★★★★★

Rated 4.8 out of 5 stars across 690+ reviews

"I have sensitive skin and this Serum leaves my face feeling soft without any burn at all."

DONNA L. · VERIFIED REVIEW

"This has worked well on my post-menopausal skin as part of my nighttime routine."

MAYA R. · VERIFIED REVIEW

"My mature skin really loves this product. It makes my complexion radiant and dewy."

ELENA S. · VERIFIED REVIEW

ADD TO BAG

Lara T.'s review is trimmed to its first clause. Confirm trimming is acceptable with Elaina, or run it in full. The Deluxe trial size rates 3.7 across 15 reviews and must stay off social-proof collateral.

PRODUCT DETAILS

Everything else you might ask.

  • Once or twice a week to begin with, at night, on clean dry skin. Build to every other night, then nightly, only as your skin tolerates it. If you get dryness or irritation, drop back a step rather than pushing through. Wear a broad spectrum sunscreen every morning while you are using it.

  • Face, neck and décolleté, at night, before your moisturizer. The neck and décolleté are the parts most people skip.

  • It is a 2.5% Bio-Retinol + Retinol Complex™, with the retinol encapsulated in evening primrose to protect its stability. Encapsulation matters as much as the number on the front: an unstable retinol degrades in the bottle, so what is on the
    label is not what reaches your skin.

  • Talk to your doctor before using any retinol product if you are pregnant, planning to be, or breastfeeding. We are not able to advise on this for you.

  • Use vitamin C in the morning and this at night rather than layering them together. Gentle exfoliation can help absorption, but do not exfoliate on the same night you apply retinol while you are still building up.

  • A fresh citrus scent from the fruit extracts and essential oils in the formula, not added perfume. The ingredient list flags d-limonene, linalool and geraniol as potential allergens, which occur naturally in those oils.

  • 30 mL / 1 fl oz. Because you build up slowly and use a small amount, most people get several months out of a bottle, longer if you are still at once or twice a week.

  • *certified organic  ·  † plant derived

    Aloe barbadensis leaf juice*, glycerin†, simmondsia chinensis (jojoba) seed oil*, coconut alkanes†, glyceryl stearate†, stearic acid†, pyrus malus (apple) juice*, vitis vinifera (grape) juice*, helianthus annuus (sunflower) seed oil*, glyceryl stearate citrate†, cetyl alcohol†, stearyl alcohol†, caprylyl glycol†, oenothera biennis (evening primrose) leaf cell extract / [retinol/soybean]†, butyrospermum parkii (shea) butter*, gossypium herbaceum (cotton) seed oil†, linum usitatissimum (linseed) oil†, bidens pilosa extract†, astrocaryum murumuru seed butter†, sodium hyaluronate (hyaluronic acid)†, ubiquinone (CoQ 10), tocopherol (Vitamin E)†, panthenol (Vitamin B5), magnesium ascorbyl phosphate (Vitamin C), coco-caprylate/caprate†, malus domestica (apple) fruit cell culture extract†, vitis vinifera (grape) fruit cell extract†, citrus limon (lemon) fruit extract†, camellia sinensis (green tea) extract*, acetyl hexapeptide-8, xanthan gum, mica, allantoin, titanium dioxide (CI 77891), ethylhexylglycerin, diheptyl succinate†, polyglyceryl-6 distearate†, capryloyl glycerin/sebacic acid copolymer†, thioctic acid (alpha lipoic), litsea cubeba oil†, cinnamomum camphora linalooliferum oil†. Potential allergens: d-limonene†, linalool†, geraniol†

Smoother, more even skin by morning.

2.5% Bio-Retinol +Retinol, encapsulated for stability. $72 for 30 mL.